Mechanism of Action of Thiazide Diuretics
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What is the primary mechanism of action of thiazide diuretics such as hydrochlorothiazide?
O They inhibit water and sodium reabsorption, increasing potassium excretion.
O They decrease sodium reabsorption in the loop of Henle.
O They increase the reabsorption of calcium in the kidneys.
O They block aldosterone receptors, retaining potassium and increasing sodium excretion.
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In this pharmacology question, we are asked for the primary mechanism of action of thiazide diuretics like hydrochlorothiazide.
Mechanism of Action: Thiazide Diuretics
Let's look at how the nephron works to understand the options.
Thiazides primarily target the distal convoluted tubule, or D C T.
At this site, they inhibit the sodium chloride symporter. By blocking the reabsorption of sodium and chloride, water follows the salt, which increases urine volume.
This leads to the primary outcome: they inhibit water and sodium reabsorption.
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